Dermapen is safer and more effective in piercing the skin than traditional skin micro needling rollers due to its unique vertical micro needling technology. It has a superior effect on collagen and elastin rejuvenation. Active ingredients are directly supplied to the deeper layers of the skin. Dermapen’s multi-speed and adjustable needle depths allow the needles to pierce the skin’s layers at 90 degrees and increases the effectiveness of treatments by increasing the absorption of products, generating less pain and downtime for the patient. Dermapen can effectively treat hard-to-reach places (e.g. around the eyes, nose, and lips). Because of the vertical delivery, the needles can easily penetrate scar tissue. Dermapen promotes scar-less healing and natural collagen reproduction, similar to fractional laser treatments, IPL, laser resurfacing, and chemical peels, but without the side effects and downtime. The mechanism of injury is a natural process, which makes Dermapen a holistic approach to skin therapy. Four major phases of physiological wound response help in stimulating new healthy tissue growth. First, an inflammatory response (1-3 days), to the initial injury promotes the chemotaxis response and proliferation of fibroblasts. The body’s platelets also respond to initiate a wound matrix. This response is the early phase of cell migration to remove debris and bacteria and stimulate the next proliferative phase. During the second phase (3-5 days), the new fibroblasts, monocytes, keratinocytes of the first phase continue to proliferate and multiply. New collagen will be laid down and deposited with new tissue formation. Next a fibrotic response (5-20 days), of growth factors are released and fibroblasts release collagen. Finally, the maturation stage of new healthy skin takes place from day 28 to two years after treatment. Collagens mature and stiffen and the matrix of new tissue shows 80% to full tensile strength.